The most important insight about P/E is that it is a snapshot of current earnings, not future earnings. A company growing earnings at 30% per year at a 40x P/E may be cheap on a five-year view, while a company with stagnant earnings at 10x P/E may be expensive. The P/E multiple is a compressed summary of the market's growth and quality expectations -- to evaluate it, you have to decompose what assumptions are embedded in that number.
A simple discipline: divide the P/E by the expected earnings growth rate to get the PEG ratio. A 40x P/E on a 40% earnings grower gives a PEG of 1.0, historically considered fair value. A 15x P/E on a 5% grower gives a PEG of 3.0, expensive regardless of how modest the absolute multiple looks. Interest rate sensitivity creates P/E regime effects independent of company quality: falling rates expand the justified multiple on all equities, especially long-duration growth assets. The 2022 rate normalization compressed high-growth P/E multiples 40-60% before earnings moved at all. Multiple compression, not earnings deterioration, drove those declines.